An efficient liposome based method for antioxidants encapsulation.
Identifieur interne : 000234 ( Main/Exploration ); précédent : 000233; suivant : 000235An efficient liposome based method for antioxidants encapsulation.
Auteurs : Marco Paini [Italie] ; Sean Ryan Daly [Australie] ; Bahar Aliakbarian [Italie] ; Ali Fathi [Australie] ; Elmira Arab Tehrany [France] ; Patrizia Perego [Italie] ; Fariba Dehghani [Australie] ; Peter Valtchev [Australie]Source :
- Colloids and surfaces. B, Biointerfaces ; 2015.
Abstract
Apigenin is an antioxidant that has shown a preventive activity against different cancer and cardiovascular disorders. In this study, we encapsulate apigenin with liposome to tackle the issue of its poor bioavailability and low stability. Apigenin loaded liposomes are fabricated with food-grade rapeseed lecithin in an aqueous medium in absence of any organic solvent. The liposome particle characteristics, such as particle size and polydispersity are optimised by tuning ultrasonic processing parameters. In addition, to measure the liposome encapsulation efficiency accurately, we establish a unique high-performance liquid chromatography technique in which an alkaline buffer mobile phase is used to prevent apigenin precipitation in the column;. salt is added to separate lipid particles from the aqeuous phase. Our results demonstrate that apigenin encapsulation efficiency is nearly 98% that is remarkably higher than any other reported value for encapsulation of this compound. In addition, the average particle size of these liposomes is 158.9±6.1nm that is suitable for the formulation of many food products, such as fortified fruit juice. The encapsulation method developed in this study, therefore have a high potential for the production of innovative, functional foods or nutraceutical products.
DOI: 10.1016/j.colsurfb.2015.10.038
PubMed: 26590900
Affiliations:
- Australie, France, Italie
- Alsace-Champagne-Ardenne-Lorraine, Lorraine
- Vandoeuvre-Lès-Nancy
- Nancy-Université
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Le document en format XML
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Research Center for Biologically Inspired Engineering in Vascular Medicine and Longevity (BELONG), Via Montallegro 1, 16145 Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Civil, Chemical and Environmental Engineering, University of Genoa, Via Opera Pia 15, 16145 Genoa, Italy; Research Center for Biologically Inspired Engineering in Vascular Medicine and Longevity (BELONG), Via Montallegro 1, 16145 Genoa</wicri:regionArea><wicri:noRegion>16145 Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Daly, Sean Ryan" sort="Daly, Sean Ryan" uniqKey="Daly S" first="Sean Ryan" last="Daly">Sean Ryan Daly</name><affiliation wicri:level="1"><nlm:affiliation>School of Chemical and Biomolecular Engineering, University of Sydney, Sydney, NSW 2006, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Chemical and Biomolecular Engineering, University of Sydney, Sydney, NSW 2006</wicri:regionArea><wicri:noRegion>NSW 2006</wicri:noRegion></affiliation></author><author><name sortKey="Aliakbarian, Bahar" sort="Aliakbarian, Bahar" uniqKey="Aliakbarian B" first="Bahar" last="Aliakbarian">Bahar Aliakbarian</name><affiliation wicri:level="1"><nlm:affiliation>Department of Civil, Chemical and Environmental Engineering, University of Genoa, Via Opera Pia 15, 16145 Genoa, Italy; Research Center for Biologically Inspired Engineering in Vascular Medicine and Longevity (BELONG), Via Montallegro 1, 16145 Genoa, Italy. 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B, Biointerfaces</title><idno type="e-ISSN">1873-4367</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Apigenin is an antioxidant that has shown a preventive activity against different cancer and cardiovascular disorders. In this study, we encapsulate apigenin with liposome to tackle the issue of its poor bioavailability and low stability. Apigenin loaded liposomes are fabricated with food-grade rapeseed lecithin in an aqueous medium in absence of any organic solvent. The liposome particle characteristics, such as particle size and polydispersity are optimised by tuning ultrasonic processing parameters. In addition, to measure the liposome encapsulation efficiency accurately, we establish a unique high-performance liquid chromatography technique in which an alkaline buffer mobile phase is used to prevent apigenin precipitation in the column;. salt is added to separate lipid particles from the aqeuous phase. Our results demonstrate that apigenin encapsulation efficiency is nearly 98% that is remarkably higher than any other reported value for encapsulation of this compound. In addition, the average particle size of these liposomes is 158.9±6.1nm that is suitable for the formulation of many food products, such as fortified fruit juice. The encapsulation method developed in this study, therefore have a high potential for the production of innovative, functional foods or nutraceutical products.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Italie</li></country><region><li>Alsace-Champagne-Ardenne-Lorraine</li><li>Lorraine</li></region><settlement><li>Vandoeuvre-Lès-Nancy</li></settlement><orgName><li>Nancy-Université</li></orgName></list><tree><country name="Italie"><noRegion><name sortKey="Paini, Marco" sort="Paini, Marco" uniqKey="Paini M" first="Marco" last="Paini">Marco Paini</name></noRegion><name sortKey="Aliakbarian, Bahar" sort="Aliakbarian, Bahar" uniqKey="Aliakbarian B" first="Bahar" last="Aliakbarian">Bahar Aliakbarian</name><name sortKey="Perego, Patrizia" sort="Perego, Patrizia" uniqKey="Perego P" first="Patrizia" last="Perego">Patrizia Perego</name></country><country name="Australie"><noRegion><name sortKey="Daly, Sean Ryan" sort="Daly, Sean Ryan" uniqKey="Daly S" first="Sean Ryan" last="Daly">Sean Ryan Daly</name></noRegion><name sortKey="Dehghani, Fariba" sort="Dehghani, Fariba" uniqKey="Dehghani F" first="Fariba" last="Dehghani">Fariba Dehghani</name><name sortKey="Fathi, Ali" sort="Fathi, Ali" uniqKey="Fathi A" first="Ali" last="Fathi">Ali Fathi</name><name sortKey="Valtchev, Peter" sort="Valtchev, Peter" uniqKey="Valtchev P" first="Peter" last="Valtchev">Peter Valtchev</name></country><country name="France"><region name="Alsace-Champagne-Ardenne-Lorraine"><name sortKey="Tehrany, Elmira Arab" sort="Tehrany, Elmira Arab" uniqKey="Tehrany E" first="Elmira Arab" last="Tehrany">Elmira Arab Tehrany</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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